Isoagglutinin reduction in intravenous immunoglobulin (IgPro10, Privigen) by specific immunoaffinity chromatography reduces its reporting rates of hemolytic reactions: an analysis of spontaneous adverse event reports.
Amgad SheblSusie GabrielKristy Van DintherAlphonse HubschJohn-Philip LawoLiane HoeffererSusan WelshPublished in: Transfusion (2020)
Following implementation of the IAC isoagglutinin reduction step, spontaneous reports of hemolytic events with IgPro10 were significantly and consistently reduced versus IgPro10 without isoagglutinin reduction, offering patients a more favorable benefit-risk profile.
Keyphrases
- adverse drug
- end stage renal disease
- newly diagnosed
- ejection fraction
- primary care
- chronic kidney disease
- mass spectrometry
- prognostic factors
- high dose
- peritoneal dialysis
- emergency department
- patient reported outcomes
- high performance liquid chromatography
- high resolution
- electronic health record
- ms ms
- simultaneous determination