Temozolomide is additive with cytotoxic effect of irradiation in canine glioma cell lines.

Nina Simona TreschDaniel FuchsLuca MorandiCaterina TononCarla Rohrer BleyKatarzyna J Nytko

Published in: Veterinary medicine and science (2021)

Hence, an additive effect of combined treatment in MGMT negative canine glial tumour cell lines in vitro was detected. This motivates to further investigate the association between treatment resistance and MGMT, such as MGMT promoter methylation status.

Keyphrases

dna methylation
gene expression
transcription factor
genome wide
spinal cord
newly diagnosed
smoking cessation