Association of mitochondrial DNA content in peripheral blood with cancer-related fatigue and chemotherapy-related cognitive impairment in early-stage breast cancer patients: a prospective cohort study.

Jung-Woo ChaePeh Siang ChuaTerence NgAngie Hui Ling YeoMaung ShweYan Xiang GanSreemanee DorajooKoon Mian FooKiley Wei-Jen LohSi-Lin KooWen Yee ChayTira Jing Ying TanSok Yuen BehElaine Hsuen LimGuek Eng LeeRebecca DentYoon Sim YapRaymond NgHan Kiat HoAlexandre Chan

Published in: Breast cancer research and treatment (2018)

This is the first study to show that the reduction of mtDNA content in peripheral blood is associated with the onset of CRF in patients receiving chemotherapy. Further validation studies are required to confirm the findings.

Keyphrases

peripheral blood
mitochondrial dna
copy number
early stage
cognitive impairment
locally advanced
squamous cell carcinoma
dna methylation
depressive symptoms
sleep quality
case control