A rare coding allele in IFIH1 is protective for psoriatic arthritis.
Ashley Budu-AggreyJohn David BowesPhilip E StuartMatthew ZawistowskiLam C TsoiRajan NairDeepak Rohit JadonNeil McHughEleanor KorendowychJames T ElderRichard B WarrenSoumya RaychaudhuriPublished in: Annals of the rheumatic diseases (2017)
For the first time, we report a rare coding allele in IFIH1 to be protective for PsA. This rare allele has also been identified to have the same direction of effect on type I diabetes and psoriasis. While this association further supports existing evidence for IFIH1 as a causal gene for PsA, mechanistic studies will need to be pursued to confirm that IFIH1 is indeed causal.