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Implementation of micelle-enabled C(sp 2 )-C(sp 3 ) cross-electrophile coupling in pharmaceutical synthesis.

Bin WuNing YeKangming ZhaoMin ShiJiayu LiaoJing ZhangWei ChenXianzhong LiYufeng HanMargery Cortes-ClergetMorgan Louis RegnierMichael ParmentierChristian MathesFlorian RampfFabrice Gallou
Published in: Chemical communications (Cambridge, England) (2024)
A sustainable C(sp 2 )-C(sp 3 ) cross-electrophile coupling was developed between readily available 5-bromophthalide and 1-benzyl-4-iodopiperidine under micellar conditions, leading to a key intermediate of one of our development compounds. Copper was found to play a crucial role as a co-catalyst in this dual catalysis system. The chemistry and process were successfully demonstrated in a kilo scale to deliver sufficient drug substance to the clinical campaigns. This is the first reported scale-up of such a challenging cross-electrophilic coupling that uses an aqueous medium, and not undesirable reprotoxic polar aprotic solvents ( e.g. DMF, DMAc, and NMP).
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