Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer.

Miquel Ensenyat-MendezJavier I J OrozcoPere Llinàs-AriasSandra Íñiguez-MuñozJennifer L BakerMatthew P SalomonMercè MartíMaggie L DiNomeJavier CortésDiego M Marzese

Published in: Communications medicine (2023)

TNBC-ICI predicts pCR to ICI plus chemotherapy in patients with primary TNBC. The study provides a guide to implementing the TNBC-ICI classifier in clinical studies. Further validations will consolidate a novel predictive panel to improve the treatment decision-making for patients with TNBC.

Keyphrases

gene expression
decision making
dna methylation
locally advanced
squamous cell carcinoma
rectal cancer