Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.

J L GoggiY X TanS V HartimathB JieuY Y HwangL JiangR BoominathanP ChengT Y YuenH X ChinJ R TangA LarbiA M ChackoL ReniaC JohannesEdward G Robins

Published in: Molecular imaging and biology (2021)

[18F]AlF-mNOTA-GZP uptake correlates well with changes in CD8+ T cell populations and is able to stratify tumour response to a range of ICIs administered as monotherapies or in combination. However, tracer uptake can be significantly affected by preexisting phenotypic abnormalities potentially confusing data interpretation.

Keyphrases

pet imaging
positron emission tomography
electronic health record
computed tomography
machine learning
artificial intelligence