Neuropsin in mental health.
Lina BukowskiAna M F ChernomorchenkoAnna StarnawskaOle MorsNicklas Heine StaunstrupAnders D BørglumPer QvistPublished in: The journal of physiological sciences : JPS (2020)
Neuropsin is a brain-expressed extracellular matrix serine protease that governs synaptic plasticity through activity-induced proteolytic cleavage of synaptic proteins. Its substrates comprise several molecules central to structural synaptic plasticity, and studies in rodents have documented its role in cognition and the behavioral and neurobiological response to stress. Intriguingly, differential usage of KLK8 (neuropsin gene) splice forms in the fetal and adult brain has only been reported in humans, suggesting that neuropsin may serve a specialized role in human neurodevelopment. Through systematic interrogation of large-scale genetic data, we review KLK8 regulation in the context of mental health and provide a summary of clinical and preclinical evidence supporting a role for neuropsin in the pathogenesis of mental illness.
Keyphrases
- mental health
- mental illness
- extracellular matrix
- white matter
- resting state
- genome wide
- endothelial cells
- high glucose
- electronic health record
- functional connectivity
- diabetic rats
- oxidative stress
- palliative care
- cerebral ischemia
- mild cognitive impairment
- cell therapy
- big data
- gene expression
- stress induced
- mesenchymal stem cells
- dna binding
- drug induced
- brain injury
- machine learning
- induced pluripotent stem cells
- protein kinase
- data analysis
- subarachnoid hemorrhage
- genome wide identification
- transcription factor
- dna methylation
- heat stress