NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.

Di LiuYu KuangSimin ChenRuiru LiFan SuShuoyang ZhangQian QiuShuibin LinChuyu ShenYingli LiuLiuqin LiangJingnan WangHanshi XuYoujun Xiao

Published in: Annals of the rheumatic diseases (2024)

Our findings uncover the important roles of NAT10-mediated ac4C modification in promoting rheumatoid synovial aggression and inflammation, indicating that NAT10 may be a potential target for the treatment of RA, even other dysregulated FLSs-associated disorders.

Keyphrases

rheumatoid arthritis
disease activity
oxidative stress
ankylosing spondylitis
interstitial lung disease
risk assessment
binding protein
combination therapy
human health