Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats.

Edward D LevinCorinne WellsAndrew HawkeyZade HollowayGraham BlairAlexander VierlingAshley KoCaroline PaceJohn ModarresAnthony McKinneyAmir H RezvaniJed E Rose

Published in: Psychopharmacology (2020)

These studies show the promise of amitifadine as a treatment for countering opiate self-administration for adjunctive use with opioids for analgesia. Further studies are needed to determine the possible efficacy of amitifadine for combating opiate addiction or preventing it in humans during adjunctive use with opioids for chronic pain.

Keyphrases

chronic pain
pain management
case control
big data
ultrasound guided
machine learning
replacement therapy
artificial intelligence
smoking cessation