Activation of M1 muscarinic acetylcholine receptors by proline-rich oligopeptide 7a (<EDGPIPP) from Bothrops jararaca snake venom rescues oxidative stress-induced neurotoxicity in PC12 cells.

Carlos Alberto-SilvaHalyne Queiroz PantaleãoBrenda Rufino da SilvaJulio Cezar Araujo da SilvaMarcela Bermudez Echeverry

Published in: The journal of venomous animals and toxins including tropical diseases (2024)

For the first time, this work provides evidence that PRO-7a-induced neuroprotection seems to be mediated through M1 mAChR activation in PC12 cells, which reduces oxidative stress independently of AsS activity and L-arginine bioavailability.

Keyphrases

oxidative stress
diabetic rats
nitric oxide
high glucose
dna damage
brain injury
mouse model
drug induced
induced apoptosis
heat stress