Intraarticular monomethyl fumarate as a perspective therapy for osteoarthritis by macrophage polarization.
Douglas Menezes de SouzaKauê Franco MalangeCatarine Massucato NishijimaBruno Henrique de Melo LimaVinicius Cooper CapetiniAlexandre L R de OliveiraGabriel Forato AnhêClaudia Herrera TambeliCarlos Amilcar ParadaPublished in: Inflammopharmacology (2024)
Our studies with EOA model induced by MIA suggest a new perspective for human treatment committed with OA based on macrophage polarization as a therapeutic target, switching the proinflammatory profile M1 to the anti-inflammatory profile M2 with DMF systematic or by MMF locally treatment according to the OA severity.