Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus.

Surangrat ThongkornSongphon KanlayaprasitKasidit KasitipraditPattanachat LertpeerapanPawinee PanjabudValerie W HuDepicha JindatipTewarit Sarachana

Published in: Biology of sex differences (2023)

Our findings suggest that AR and other ASD-related TFs are involved in sex differences in the effects of prenatal BPA exposure on transcriptome profiles and synaptogenesis in the offspring hippocampus. These TFs may play an essential role in an increased ASD susceptibility associated with endocrine-disrupting chemicals, particularly BPA, and the male bias of ASD.

Keyphrases

autism spectrum disorder
intellectual disability
attention deficit hyperactivity disorder
high fat diet
transcription factor
rna seq
single cell
gene expression
genome wide
pregnant women
type diabetes
cerebral ischemia
metabolic syndrome
skeletal muscle
insulin resistance
drug induced
genome wide identification