Genetics of validated Parkinson's disease subtypes in the Oxford Discovery and Tracking Parkinson's cohorts.

Michael A Lawton Manuela M X TanYoav Ben-ShlomoFahd BaigThomas BarberJohannes C KleinSamuel G EvettsStephanie MillinNaveed MalekKatherine GrossetRoger A BarkerNigel WilliamsDavid J BurnThomas Foltynie Huw R MorrisNicholas WoodDonald G GrossetMichele Tao-Ming Hu

Published in: Journal of neurology, neurosurgery, and psychiatry (2022)

We have found that four previously defined PD subtypes have different genetic determinants which will help to inform future studies looking at underlying disease mechanisms and pathogenesis in these different subtypes of disease.

Keyphrases

genome wide
gene expression
copy number