Synthesis by microwave irradiation, molecular structural analysis and trypanocidal activity of novel pyrazole-tetrahydropyrimidine derivatives.

Cynthia Nathalia PereiraJúlia Akihoshi de OliveiraLeonardo da Silva LaraLorraine Martins Rocha OrlandoMirian Claudia de Souza PereiraMaurício Silva Dos Santos

Published in: Current organic synthesis (2023)

The attractive features of this synthetic methodology are mild conditions, short reaction time, and low power. All derivatives showed low toxicity in mammalian cells, good oral bioavailability, and did not violate Lipinski´s rule of 5.

Keyphrases

oxidative stress
molecular docking
structure activity relationship
radiation therapy
single molecule
molecular dynamics simulations