Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing.
Yuewei XiJuan GeMin WangMi ChenWen NiuWei ChengYumeng XueCai LinBo LeiPublished in: ACS nano (2020)
Traditional skin tumor surgery and chronic bacterial-infection-induced wound healing/skin regeneration is still a challenge. The ideal strategy should eliminate the tumor, enhance wound healing/skin formation, and be anti-infection. Herein, we designed a multifunctional elastomeric poly(l-lactic acid)-poly(citrate siloxane)-curcumin@polydopamine hybrid nanofibrous scaffold (denoted as PPCP matrix) for tumor-infection therapy and infection-induced wound healing. The PPCP matrix showed intrinsically multifunctional properties including antioxidative, anti-inflammatory, photothermal, antibacterial, anticancer, and angiogenesis bioactivities. The polydopamine/curcumin presented an excellent near-infrared photothermal/cancer cell toxicity capacity, respectively, which supported PPCP for synergetic skin tumor therapy and antibacterial properties in vitro/in vivo. Additionally, the PPCP nanofibrous matrix significantly promotes the adhesion and proliferation of normal skin cells and accelerates the cutaneous wound healing in normal mice and bacterial-infected mice by enhancing the early angiogenesis. The PPCP nanofibrous matrix with multifunctional bioactivities provides a competitive strategy for skin tumor and bacterial-infection-induced wound healing.
Keyphrases
- wound healing
- anti inflammatory
- high glucose
- drug delivery
- diabetic rats
- drug induced
- tissue engineering
- signaling pathway
- minimally invasive
- stem cells
- endothelial cells
- type diabetes
- induced apoptosis
- metabolic syndrome
- cell proliferation
- acute coronary syndrome
- cystic fibrosis
- stress induced
- bone marrow
- vascular endothelial growth factor
- escherichia coli
- percutaneous coronary intervention
- staphylococcus aureus
- magnetic nanoparticles
- rectal cancer