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High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma.

Dana WestphalM GarzarolliM SergonPeter HorakBarbara HutterJ C BeckerM WiegelE MaczeySophia Freya Ulrike BlumS Grosche-SchleeA RüttenSelma UgurelAlbrecht StenzingerHanno GlimmDaniela E AustG BarettonStefan BeissertStefan FröhlingSilke RedlerHarald M SurowyFriedegund Meier
Published in: The British journal of dermatology (2021)
Molecular profiling demonstrated high TMB and EGFR/MAPK pathway activation to be novel therapeutic targets in mEPC.
Keyphrases
  • small cell lung cancer
  • signaling pathway
  • epidermal growth factor receptor
  • tyrosine kinase
  • oxidative stress
  • pi k akt
  • squamous cell carcinoma
  • risk factors