Pneumococcal colonization and invasive disease studied in a porcine model.
Astrid de GreeffSaskia van SelmHerma BuysJosé F Harders-WesterveenRahajeng N TunjungputriQuirijn de MastAndre J van der VenNorbert Stockhofe-ZurwiedenMarien I de JongeHilde E SmithPublished in: BMC microbiology (2016)
This demonstrates that central aspects of human pneumococcal infections can be modelled in piglets enabling the use of this model for studies on colonization and transmission but also on development of vaccines and host-directed therapies. Moreover this is the first example of an animal model inducing high levels of pneumococcal septic arthritis.