Independence of HIF1a and androgen signaling pathways in prostate cancer.

Maxine G B TranBecky A S BibbyLingjian YangFranklin LoAnne Y WarrenDeepa ShuklaMichelle OsborneJames HadfieldThomas CarrollRory StarkHelen ScottAntonio Ramos-MontoyaCharlie MassiePatrick MaxwellCatharine M L WestIan Geoffrey MillsDavid E Neal

Published in: BMC cancer (2020)

The oncogenic AR, hypoxia and HIF1a pathways support prostate cancer development through independent signaling pathways and transcriptomic profiles. AR and hypoxia/HIF1a signaling pathways independently promote prostate cancer progression and therapeutic targeting of both pathways simultaneously is warranted.

Keyphrases

prostate cancer
signaling pathway
radical prostatectomy
endothelial cells
pi k akt
transcription factor
single cell
rna seq