Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications.

Ioannis P TrougakosKimon StamatelopoulosEvangelos TerposOurania E TsitsilonisEvmorfia AivaliotiDimitrios ParaskevisEfstathios KastritisGeorge N PavlakisMeletios A Dimopoulos

Published in: Journal of biomedical science (2021)

Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related "cytokine storm" and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.

Keyphrases

sars cov
life cycle
immune response
respiratory syndrome coronavirus
risk factors
acute respiratory distress syndrome
coronavirus disease
oxidative stress
extracorporeal membrane oxygenation
dendritic cells
drug induced
intensive care unit