Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles.
Adrian GerickeCarolina MannJenia Kouchek ZadehAytan MusayevaIsmael WolffMaoren WangNorbert PfeifferAndreas DaiberHuige LiNing XiaVerena ProkoschPublished in: Oxidative medicine and cellular longevity (2019)
Our data provide first-time evidence that IOP elevation impairs autoregulation and induces endothelial dysfunction in mouse retinal arterioles. Oxidative stress and inflammation, but not hypoxia, appear to be involved in this process.