Efficacy of metformin and electrical pulses in breast cancer MDA-MB-231 cells.
Praveen SahuIgnacio G CamarilloRaji SundararajanPublished in: Exploration of targeted anti-tumor therapy (2024)
The results indicate the enhanced anticancer effect of Met in the presence of electric pulses. The cell growth is inhibited by suppressing glucose levels and elevated ROS. This shows a synergistic interplay between electroporation, Met, glucose, and ROS metabolic alterations. The results show promises for combinational therapy in TNBC patients.
Keyphrases
- end stage renal disease
- cell death
- cell cycle arrest
- ejection fraction
- induced apoptosis
- newly diagnosed
- tyrosine kinase
- reactive oxygen species
- peritoneal dialysis
- prognostic factors
- type diabetes
- stem cells
- adipose tissue
- oxidative stress
- cancer therapy
- cell proliferation
- blood pressure
- skeletal muscle
- insulin resistance
- mesenchymal stem cells
- bone marrow
- young adults
- weight loss
- smoking cessation