Sennoside A Induces GLP-1 Secretion Through Activation of the ERK1/2 Pathway in L-Cells.

Li MaXinyu CaoXiaotong YeJianping YeYongning Sun

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)

The present study provides a direct evidence for the interaction between SA and L cells for induction of GLP-1 secretion. These data suggest that GLP-1 secretion induced by SA is dependent on the ERK1/2 signaling pathway. Therefore, the SA is a new drug candidate for the type 2 diabetes treatment by induction of GLP-1 secretion.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
type diabetes
cell proliferation
endoplasmic reticulum stress
cardiovascular disease
oxidative stress
cell death
electronic health record
emergency department
machine learning
metabolic syndrome
insulin resistance
skeletal muscle