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TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest.

Alessio De MagisPhilipp SchultAntonia SchönleberRebecca LinkeKerstin U LudwigBeate M KümmererKatrin Paeschke
Published in: BMC biology (2024)
These findings uncover a novel mechanism in which G4 stabilization impacts SARS-CoV-2 replication by changing TMPRSS2 isoform 1 gene expression.
Keyphrases
  • sars cov
  • gene expression
  • respiratory syndrome coronavirus
  • dna methylation
  • cell proliferation