Does synovial sarcoma grade predict oncologic outcomes, and does a low-grade variant exist?

Michael P FiceAbdullah AlmajnooniCharles GushoReagan S ChapmanSubramanya MallikarjunappaMarta BatusSteven GitelisMatthew ColmanIra MillerAlan T Blank

Published in: Journal of surgical oncology (2022)

Tumor grade appears to predict outcomes in SS. A theoretical Grade 1 group showed improved OS and RFS versus Grades 2 and 3 SS, with metastatic rates and long-term survival resembling the historical literature for other low-grade soft tissue sarcomas. Our group continues to support the French Federation of Cancer Centers diagnostic strategy and NCCN treatment guidelines for SS.

Keyphrases

low grade
high grade
soft tissue
systematic review
small cell lung cancer
papillary thyroid
prostate cancer
rectal cancer
clinical practice
squamous cell
combination therapy
glycemic control