Structural renal abnormalities in the DICER1 syndrome: a family-based cohort study.
Nicholas E KhanAlexander LingMolly E RaskeLaura A HarneyAnn G CarrAmanda FieldAnne K HarrisGretchen M WilliamsLouis P DehnerYoav H MessingerD Ashley HillKris Ann P SchultzDouglas R StewartPublished in: Pediatric nephrology (Berlin, Germany) (2018)
Our report is the first to systematically characterize renal function and anatomy in a large prospective cohort of DICER1-carriers and DICER1-negative family controls. DICER1-carriers may be at increased risk of structural anomalies of the kidney or collecting system. The role for DICER1 in renal morphogenesis merits additional investigation.
Keyphrases