NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins.
Samal BissenovaDarcy EllisAïsha CallebautGuy EelenRita DeruaMijke BuitingaChantal MathieuConny GysemansLut OverberghPublished in: Cells (2023)
The NETome of people with established T1D was enriched in metabolic proteins without an apparent alteration in the bio-energetic profile or dysregulated NETosis. This may reflect an adaptation mechanism employed by activated T1D neutrophils to avoid impaired glycolysis and consequently excessive or suboptimal NETosis, pivotal in innate immune defence and the resolution of inflammation.