ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/β-catenin pathway.
Yuanlong LiYao KongMingjie AnYuming LuoHanhao ZhengYan LinJiancheng ChenJin YangLibo LiuBaoming LuoJian HuangTianxin LinChanghao ChenPublished in: Journal of experimental & clinical cancer research : CR (2023)
Our study highlights that circNIPBL-induced Wnt signaling pathway activation triggers ZEB1-mediated circNIPBL biogenesis, which forms a positive feedback loop via the circNIPBL/miR-16-2-3p/Wnt5a/ZEB1 axis, supporting circNIPBL as a novel therapeutic target and potential biomarker for BCa patients.
Keyphrases
- epithelial mesenchymal transition
- cell proliferation
- signaling pathway
- stem cells
- long non coding rna
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- transcription factor
- high glucose
- endothelial cells
- oxidative stress
- drug induced
- induced apoptosis
- endoplasmic reticulum stress