The effects of hydroxychloroquine on insulin sensitivity, insulin clearance and inflammation in insulin-resistant adults: A randomized trial.

Frederico G S Toledo Rachel G MillerNicole L HelblingYingze ZhangJames P DeLany

Published in: Diabetes, obesity & metabolism (2021)

HCQ selectively enhances insulin sensitivity and glucose disposal in skeletal muscle, without affecting hepatic insulin sensitivity or insulin clearance. These findings offer a mechanistic explanation for the antidiabetic properties of HCQ and suggest that this medication might be useful in conditions linked to insulin resistance such as type 2 diabetes.

Keyphrases

type diabetes
insulin resistance
glycemic control
skeletal muscle
blood glucose
oxidative stress
high fat diet
cardiovascular disease
polycystic ovary syndrome
metabolic syndrome
healthcare
high fat diet induced
emergency department
weight loss
heavy metals
blood pressure
drug induced