Association between the single nucleotide variants of the mitochondrial cytochrome B gene (MT-CYB) and the male infertility.

Mayyas Saleh Jaweesh Mohamad Eid Hammadeh Fatina W Dahadhah Mazhar Salim Al Zoubi Houda Amor

Published in: Molecular biology reports (2022)

The current study showed a significant association between the MT-CYB gene polymorphisms and the development of male infertility. In particular, rs527236194, rs28357373 and rs41504845 variants were found to be the most related to the subfertility group. Further studies on larger and other populations are required to reveal the exact role of this gene in the development of male infertility. In addition, functional studies will be helpful to elucidate the molecular impact of the MT-CYP polymorphisms on mitochondrial function.

Keyphrases

copy number
genome wide
polycystic ovary syndrome
oxidative stress
type diabetes
genome wide identification
gene expression
metabolic syndrome
insulin resistance
single molecule
skeletal muscle