Pulmonary Exacerbation of Undiagnosed Toxocariasis in Intensively-Treated High-Risk Neuroblastoma Patients.
Szymon JanczarMonika BulasJustyna WalenciakDobromila BaranskaMarek UssowiczWojciech MlynarskiBeata Zalewska-SzewczykPublished in: Children (Basel, Switzerland) (2020)
Toxocariasis is one of the most common zoonoses, with high seroprevalence in apparently healthy individuals. Neuroblastoma is an aggressive childhood cancer. The cure rates are improving due to dose-dense chemotherapy, progress in surgical practice, myeloablative therapy with autologous stem cell transplantation, and recently, anti-GD2 immunotherapy. This is associated with a burden of complications, some of which are relatively specific for neuroblastoma treatment. Based on previous reports of Toxocara canis infection in high-risk neuroblastoma patients and cases of pulmonary exacerbation from our center in this disease, we propose that toxocariasis is a specific complication of intensive pediatric cancer treatment and advocate for active surveillance.
Keyphrases
- stem cell transplantation
- end stage renal disease
- newly diagnosed
- chronic obstructive pulmonary disease
- ejection fraction
- chronic kidney disease
- pulmonary hypertension
- peritoneal dialysis
- primary care
- risk factors
- stem cells
- intensive care unit
- bone marrow
- squamous cell carcinoma
- low dose
- young adults
- acute myeloid leukemia
- cell therapy
- patient reported outcomes
- acute respiratory distress syndrome
- allogeneic hematopoietic stem cell transplantation
- rectal cancer
- respiratory failure
- patient reported
- adverse drug