Leptin impairs the therapeutic effect of ionizing radiation in oral squamous cell carcinoma cells.

Rogério Gonçalves da RochaEliane Macedo Sobrinho SantosEloá Mangabeira SantosEmisael Stênio Batista GomesGuilherme Veloso RamosKarina Marini AguiarBruno Rodrigues GonçalvesSérgio Henrique Sousa SantosAlfredo Maurício Batista De PaulaAndre Luiz Sena Guimaraes Lucyana Conceição Farias

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

Our findings suggest that leptin impairs responsivity of OSCC cells to the ionizing radiation, reducing the suppressive effects of irradiation on the neoplastic phenotype, and increasing protein expression critical to carcinogenesis.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress
radiation induced