Efficient preclinical treatment of cortical T cell acute lymphoblastic leukemia with T lymphocytes secreting anti-CD1a T cell engagers.

Anaïs Jiménez-Reinoso Néstor TiradoAlba Martinez-MorenoVíctor M Diaz Marina García-PeydróOana HangiuLaura Díez-AlonsoÁngela AlbitrePetronila Penela María Luisa Toribio Pablo Menéndez Luis Alvarez-Vallina Diego Sánchez-Martínez

Published in: Journal for immunotherapy of cancer (2022)

Our data suggest that CD1a-STAb T cells could be an alternative to CD1a-CAR T cells in coT-ALL patients with aggressive and hyperleukocytic relapses with limited numbers of non-leukemic effector T cells.

Keyphrases

acute lymphoblastic leukemia
nk cells
acute myeloid leukemia
dendritic cells
machine learning
stem cells
big data
regulatory t cells
immune response
artificial intelligence