The combination of DNA methylome and transcriptome revealed the intergenerational inheritance on the influence of advanced maternal age.
Lingyue HuaWei ChenYan MengMeng QinZhiqiang YanRui YangQiang LiuYuan WeiYangyu ZhaoLiying YanJie QiaoPublished in: Clinical and translational medicine (2022)
Our results reveal potential intergenerational inheritance of both AMA-related DNA methylome and transcriptome and provide new insights to understand health problems in AMA offspring.
Keyphrases
- single cell
- rna seq
- circulating tumor
- genome wide
- mental health
- mitochondrial dna
- cell free
- single molecule
- gene expression
- public health
- high fat diet
- copy number
- human health
- birth weight
- health information
- circulating tumor cells
- metabolic syndrome
- type diabetes
- risk assessment
- insulin resistance
- physical activity
- body mass index
- skeletal muscle
- preterm birth