Transfer-catalyst-free biomimetic asymmetric reduction of 3-sulfonyl coumarins with a regenerable NAD(P)H model.
Zhou-Hao ZhuYi-Xuan DingYong-Gui ZhouPublished in: Chemical communications (Cambridge, England) (2022)
A novel transfer-catalyst-free biomimetic reduction of the tetrasubstituted olefins 3-sulfonyl coumarins with the chiral and regenerable [2.2]paracyclophane-based NAD(P)H model CYNAM has been developed, affording chiral 3-sulfonyl dihydrocoumarins with excellent enantioselectivities.