Exploring the preparation of multifunctional hydrogels from a bionic perspective is an appealing strategy. Here, we prepared a multifunctional hydrogel dressing inspired by the characteristics of porous extracellular matrix produced during Acomys wound healing. These dressings were printed by Digital Light Processing (DLP) printing of hydrogels composed of gelatin methacrylate (GelMA), hyaluronic acid methacrylate (HAMA), and pretreated platelet-rich plasma (PRP) to shape out triply periodic minimal surface (TPMS) structures, which were freeze-dried for long-term storage. These dressings mimic the porous extracellular matrix of Acomys, while the freeze-drying technique effectively extended the storage duration of PRP viability. Through in vivo and in vitro experiments, the biomimetic dressings developed in this study modulated cell behavior and facilitated wound healing. Consequently, this research offers a novel approach for the advancement of regenerative wound dressings. This article is protected by copyright. All rights reserved.