Three New Oleanane-Type Triterpenoidal Glycosides from Impatiens balsamina and Their Biological Activity.
Tae Hyun LeeWon Se SuhLalita SubediSun Yeou KimSang Un ChoiKang Ro LeeChung Sub KimPublished in: Plants (Basel, Switzerland) (2020)
Three new oleanane-type triterpenoidal glycosides, imbalosides A-C (1-3), were isolated from the white flowers of Impatiens balsamina. The structures of these phytochemical constituents (1-3) were elucidated through 1D and 2D Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) data analyses followed by chemical methods. All the characterized compounds (1-3) were evaluated for their antiproliferative activity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and BT549) and their anti-neuroinflammatory activity on the basis of inhibition levels of nitric oxide (NO) in the lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cell lines.
Keyphrases
- magnetic resonance
- mass spectrometry
- inflammatory response
- nitric oxide
- high resolution
- lps induced
- lipopolysaccharide induced
- endothelial cells
- liquid chromatography
- multiple sclerosis
- toll like receptor
- electronic health record
- ms ms
- capillary electrophoresis
- gas chromatography
- computed tomography
- hydrogen peroxide
- artificial intelligence
- machine learning
- deep learning
- data analysis