Internal Alkyne-Directed Fluorination of Unactivated C(sp3)-H Bonds.
Chenyun ShuJian FengHanliang ZhengCungui ChengZheliang YuanZuxiao ZhangXiao-Song XueGangguo ZhuPublished in: Organic letters (2020)
A silver-mediated internal alkyne-guided fluorination of unactivated C(sp3)-H bonds is described. The reaction provides a facile access to γ-fluorinated fluoroalkylated (Z)-alkenes from readily available alkynes in promising yields with excellent regioselectivity, stereoselectivity, and site selectivity.