Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8 + T cells.
Frances WinklerAnna V HippCarlos RamirezBianca MartinMatteo VillaEmilia NeuwirtOliver GorkaJeroen AerssensSusanne E JohanssonNisha RanaSian Llewellyn-LaceyDavid A PriceMarcus PanningOlaf GroßErika L PearceCarl M HermannKathrin SchumannLuciana HannibalChristoph Neumann-HaefelinTobias BoettlerPercy KnolleMaike HofmannDirk WohlleberRobert ThimmeBertram BengschPublished in: Gut (2023)
Metabolism of HBV-specific and HCV-specific T cells is strongly connected to their exhaustion severity. Our results highlight enolase as metabolic regulator of severely exhausted T cells. They connect differential bioenergetic fitness with distinct exhaustion subtypes and varying liver disease, with implications for therapeutic strategies.