Causal relationship between inflammatory factors and cerebral small vessel disease: Univariate, multivariate, and summary-data-based mendelian randomization analysis.

Tian-Ci QiaoHao-Yu TianShi-Zhe ShanLi-Li ShanZheng-Yu PengJia KeMeng-Ting LiYang WuYan Han

Published in: Brain and behavior (2024)

According to MR and SMR analysis, higher levels of TRAIL increased the risk of SVS by upregulating gene expression of KNG1 in brain cortex tissues. In addition, protective effects of E-selectin and IL-3a levels on WMPVS were regulated by increased DNA methylation of gene ABO in blood tissue.

Keyphrases

gene expression
dna methylation
genome wide
magnetic resonance
subarachnoid hemorrhage
copy number
oxidative stress
electronic health record
white matter
multiple sclerosis
computed tomography
machine learning
big data
functional connectivity
genome wide identification