Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality.
Hong WangRan JingChrista TrexlerYali LiHuayuan TangZhixiang PanSiting ZhuBeili ZhaoXi FangJie LiuJu ChenKunfu OuyangPublished in: Journal of gastroenterology (2018)
Here, we provided a novel mouse model for impaired GI motility and demonstrated that IP3R1 plays a critical role in regulating physiological function of GI tract in vivo.