Genotype prediction of ATRX mutation in lower-grade gliomas using an MRI radiomics signature.

• ATRX in lower-grade gliomas could be predicted using radiomic analysis. • The LASSO regression algorithm and SVM performed well in radiomic analysis. • Nine radiomic features were screened as an ATRX-predictive radiomic signature. • The machine-learning model for ATRX-prediction was validated by an independent database.