Aldehyde dehydrogenase 1 a1 regulates energy metabolism in adipocytes from different species.
Kefeng YangChristopher AdinQiwen ShenLy James LeeLianbo YuPaolo FaddaArpad SamogyiKathleen HamLu XuChen GilorOuliana ZiouzenkovaPublished in: Xenotransplantation (2017)
Our data demonstrate the functional exchange of regulatory factors between adipocytes from different species for regulation of energy balance. RBP4 and LCN2 appear to be involved in the transport of retinoids for regulation of lipid accumulation and thermogenesis in xenocultures. While the rarity of thermogenic adipocytes in humans and dogs precludes their use for autologous transplantation, our study demonstrates that xenotransplantation of engineered cells could be a potential solution for the reduction in obesity in dogs and a strategy for translation to patients.
Keyphrases
- adipose tissue
- high fat diet induced
- insulin resistance
- induced apoptosis
- end stage renal disease
- ejection fraction
- metabolic syndrome
- newly diagnosed
- type diabetes
- cell therapy
- prognostic factors
- bone marrow
- weight loss
- transcription factor
- cell cycle arrest
- patient reported outcomes
- cell death
- mesenchymal stem cells
- body mass index
- genetic diversity
- physical activity