MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia.

Bing LiuHongye MaQianqian LiuYang XiaoShimeng PanHuimin ZhouLi Jia

Published in: Journal of experimental & clinical cancer research : CR (2019)

These data indicated that miR-29b/Sp1/FUT4 axis promoted the malignant behaviors of LSCs by regulating fucosylated CD44 via Wnt/β-catenin pathway. Identifying LSCs surface markers and targeting LSCs were important for the development of potential therapies in AML.

Keyphrases

stem cells
acute myeloid leukemia
cell proliferation
bone marrow
electronic health record
cell therapy
cancer therapy
big data
machine learning
drug delivery
risk assessment
artificial intelligence