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MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia.

Bing LiuHongye MaQianqian LiuYang XiaoShimeng PanHuimin ZhouLi Jia
Published in: Journal of experimental & clinical cancer research : CR (2019)
These data indicated that miR-29b/Sp1/FUT4 axis promoted the malignant behaviors of LSCs by regulating fucosylated CD44 via Wnt/β-catenin pathway. Identifying LSCs surface markers and targeting LSCs were important for the development of potential therapies in AML.
Keyphrases
  • stem cells
  • acute myeloid leukemia
  • cell proliferation
  • bone marrow
  • electronic health record
  • cell therapy
  • cancer therapy
  • big data
  • machine learning
  • drug delivery
  • risk assessment
  • artificial intelligence