Nucleolar Localization of the RNA Helicase DDX21 Predicts Survival Outcomes in Gynecologic Cancers.

Marwa W Aljardali Kevin M Kremer Jessica E Parker Elaine Fleming Hao Chen Jayanthi S Lea W Lee Kraus Cristel V Camacho

Published in: Cancer research communications (2024)

Currently, there are no reliable biomarkers for response to PARPi outside of homologous recombination deficiency. Herein we present a unique potential biomarker, with clear functional understanding of the molecular mechanism by which DDX21 nucleolar localization can predict response to PARPi.

Keyphrases

dna repair
dna damage
young adults