Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy.
Jacek KwiecinskiRoss J LennenGillian A GrayGary BorthwickLyndsey BoswellAndrew H BakerDavid E NewbyMarc R DweckMaurits A JansenPublished in: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2020)
We have established and characterized angiotensin II infusion and repeated CMR imaging as a model of LV hypertrophy and reverse remodelling in response to systemic hypertension. Changes in myocardial fibrosis and alterations in cardiac function are only partially reversible following relief of hypertension.
Keyphrases
- left ventricular
- angiotensin ii
- blood pressure
- mouse model
- heart failure
- vascular smooth muscle cells
- angiotensin converting enzyme
- high resolution
- low dose
- hypertrophic cardiomyopathy
- acute myocardial infarction
- cardiac resynchronization therapy
- left atrial
- aortic stenosis
- arterial hypertension
- atrial fibrillation