Pinus halepensis Essential Oil Ameliorates Aβ1-42-Induced Brain Injury by Diminishing Anxiety, Oxidative Stress, and Neuroinflammation in Rats.
Paula Alexandra PostuMarius MihasanDragos Lucian GorganFatima Zahra SadikiMostafa El IdrissiLucian HritcuPublished in: Biomedicines (2022)
The Pinus L. genus comprises around 250 species, being popular worldwide for their medicinal and aromatic properties. The present study aimed to evaluate the P. halepensis Mill. essential oil (PNO) in an Alzheimer's disease (AD) environment as an anxiolytic and antidepressant agent. The AD-like symptoms were induced in Wistar male rats by intracerebroventricular administration of amyloid beta1-42 (Aβ1-42), and PNO (1% and 3%) was delivered to Aβ1-42 pre-treated rats via inhalation route for 21 consecutive days, 30 min before behavioral assessments. The obtained results indicate PNO's potential to relieve anxious-depressive features and to restore redox imbalance in the rats exhibiting AD-like neuropsychiatric impairments. Moreover, PNO presented beneficial effects against neuroinflammation and neuroapoptosis in the Aβ1-42 rat AD model.
Keyphrases
- essential oil
- oxidative stress
- diabetic rats
- high glucose
- traumatic brain injury
- lipopolysaccharide induced
- cerebral ischemia
- drug induced
- major depressive disorder
- bipolar disorder
- cognitive impairment
- resting state
- ischemia reperfusion injury
- cognitive decline
- physical activity
- brain injury
- blood brain barrier
- functional connectivity
- climate change
- stress induced