Evaluation of Zuo-Gui Yin Decoction Effects on Six CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS.

Bangzhen HongShizhong HongXuerui HuFan HeXiaoxiao ShanLei Wang Wei-Dong Chen

Published in: BioMed research international (2022)

The results showed that ZGYD exhibited the induction effects on CYP2C11 and CYP3A1 (CYP2C19 and CYP3A4 in humans) in rats. However, no significant change in CYP1A2, CYP2B1, CYP2C7, and CYP2D2 activities was observed. It would be useful for the safe and effective usage of ZGYD in clinic.

Keyphrases

ms ms
primary care
simultaneous determination
liquid chromatography tandem mass spectrometry
solid phase extraction