Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities.
Salem S SalemAmr Hosny HashemAl-Aliaa M SallamAhmed S DoghishAbdulaziz A Al-AskarAmr A ArishiAmr M ShehabeldinePublished in: Polymers (2022)
Traditional cancer treatments include surgery, radiation, and chemotherapy. According to medical sources, chemotherapy is still the primary method for curing or treating cancer today and has been a major contributor to the recent decline in cancer mortality. Nanocomposites based on polymers and metal nanoparticles have recently received the attention of researchers. In the current study, a nanocomposite was fabricated based on carboxymethyl cellulose and silver nanoparticles (CMC-AgNPs) and their antibacterial, antifungal, and anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs have promising antibacterial activity against Gram-negative ( Klebsiella oxytoca and Escherichia coli ) and Gram-positive bacteria ( Bacillus cereus and Staphylococcus aureus ). Moreover, CMC-AgNPs exhibited antifungal activity against filamentous fungi such as Aspergillus fumigatus , A. niger , and A. terreus. Concerning the HepG2 hepatocellular cancer cell line, the lowest IC 50 values (7.9 ± 0.41 µg/mL) were recorded for CMC-AgNPs, suggesting a strong cytotoxic effect on liver cancer cells. As a result, our findings suggest that the antitumor effect of these CMC-Ag nanoparticles is due to the induction of apoptosis and necrosis in hepatic cancer cells via increased caspase-8 and -9 activities and diminished levels of VEGFR-2. In conclusion, CMC-AgNPs exhibited antibacterial, antifungal, and anticancer activities, which can be used in the pharmaceutical and medical fields.
Keyphrases
- silver nanoparticles
- papillary thyroid
- gram negative
- escherichia coli
- squamous cell
- staphylococcus aureus
- healthcare
- candida albicans
- cell death
- lymph node metastasis
- oxidative stress
- type diabetes
- minimally invasive
- multidrug resistant
- reduced graphene oxide
- pseudomonas aeruginosa
- squamous cell carcinoma
- cardiovascular disease
- locally advanced
- rectal cancer
- risk factors
- cardiovascular events
- signaling pathway
- gold nanoparticles
- radiation therapy
- biofilm formation
- endothelial cells
- high resolution
- drinking water
- mass spectrometry
- klebsiella pneumoniae
- percutaneous coronary intervention
- cell cycle arrest
- liquid chromatography
- vascular endothelial growth factor
- simultaneous determination