Voxel-based superimposition of serial craniofacial CBCTs: Reliability, reproducibility and segmentation effect on hard-tissue outcomes.

The tested voxel-based superimposition method presented good efficiency, cranial base matching and reproducibility in a growing patient sample. Segmentation error was considered minimal. The total error reached clinically relevant levels in very few cases. Thus, this technique is considered appropriate for clinical use, when 3D assessment of craniofacial changes is required.